TECHNOLOGIES

Rabbit Mass
Humanization

This platform opens the possibility to generate human antibodies starting with in vivo immunization of rabbits using proteins, peptides, cDNA or cell lines.
 

The novel mass humanization technology yields fully human antibodies with excellent drug-like properties in a fast and straightforward workflow

Rabbits produce robust antibodies and show a strong immune response even against challenging targets. AbCheck’s Rabbit Mass Humanization technology provides a new solution for the humanization of entire rabbit immune repertoires. Our technique reaches a higher degree of similarity to human molecules compared to classic CDR grafting approaches.
Principle
of Design
Rabbit clonal lineage analysis: Rabbit immune repertoire can be captured into four selected human scaffolds
Designed diversity in CDR1/2 representing all possible humanizations including maximal germlining
CDR-H3 and CDR-L3 diversity are transferred from immunized rabbits into the humanization library
AbCheck has repeatedly succeeded in identifying highly specific binders to challenging targets by using the Mass Humanization Library
TECHNOLOGY DIAGRAM

Rabbit Mass Humanization Principle

TECHNOLOGY DIAGRAM
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