The novel mass humanization technology yields fully human antibodies with excellent drug-like properties in a fast and straightforward workflow
Rabbits produce robust antibodies and show a strong immune response even against challenging targets. AbCheck’s Rabbit Mass Humanization technology provides a new solution for the humanization of entire rabbit immune repertoires. Our technique reaches a higher degree of similarity to human molecules compared to classic CDR grafting approaches.
Rabbit clonal lineage analysis: Rabbit immune repertoire can be captured into four selected human scaffolds
Designed diversity in CDR1/2 representing all possible humanizations including maximal germlining
CDR-H3 and CDR-L3 diversity are transferred from immunized rabbits into the humanization library
AbCheck has repeatedly succeeded in identifying highly specific binders to challenging targets by using the Mass Humanization Library