TECHNOLOGIES

AbAccelTM
Antibody Optimization

AbAccel™ is an innovative platform focused on developability that enables multi-factor antibody optimization in a single process.
 

Existing antibody molecules are converted in proprietary AbAccel™ libraries and screened for variants with optimized affinities and biophysical properties

Proprietary AbAccel™ libraries are cloned for existing lead candidates and screened for variants with optimized affinities and biophysical properties. AbAccel™ has identified optimized antibody candidates that demonstrated a more than 100-fold improved affinity, while preserving other properties such as species cross-reactivity, specificity and stability.

Lead optimization with AbAccel™ is based on a proprietary algorithm. HCDR3 regions of lead candidates are identified and transferred to a compatible VH/VL framework pair with proven performance for GMP production.

TECHNOLOGY DIAGRAM

Affinity Maturation & Optimization Principle

TECHNOLOGY DIAGRAM
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AbSieve™
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Proprietary
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Antibody
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AbAccel™
Antibody
Optimization

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