TECHNOLOGIES

AbAccel®
Antibody Optimization

AbAccel® is an innovative platform focused on developability that enables multi-factor antibody optimization in a single process.
 

Existing antibody molecules are converted in proprietary AbAccel® libraries and screened for variants with optimized affinities and biophysical properties

Proprietary AbAccel® libraries are cloned for existing lead candidates and screened for variants with optimized affinities and biophysical properties. AbAccel® has identified optimized antibody candidates that demonstrated a more than 100-fold improved affinity, while preserving other properties such as species cross-reactivity, specificity and stability. Lead optimization with AbAccel® is based on a proprietary algorithm. HCDR3 regions of lead candidates are identified and transferred to a compatible VH/VL framework pair with proven performance for GMP production.

TECHNOLOGY DIAGRAM

Affinity Maturation & Optimization Principle

TECHNOLOGY DIAGRAM
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AbSieve®
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Antibody
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AbAccel®
Antibody
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