SERVICES

Antibody
Optimization

We optimize antibody sequences for best in class therapeutic applications
Overview
AbCheck will become your partner in the antibody optimization, aligning the workflow process with your desired product profile and endpoints for your antibody and its therapeutic application. Our unique technology allows affinity maturation of antibodies as well as the removal of biochemical and biophysical liabilities. Our method delivers panels of sequence variants and reveals valuable information on the paratope of your antibody.
We achieve improvement in affinity with optimal species cross-reactivity and thermal stability in a single process
Key
Components
1 100-fold affinity improvement compared to human and cyno target
2 Quality upgrades and final optimization before product development
3 Enhanced developability and target affinity via use of special library designs and frameworks with excellent biophysical properties
4 Valuable information for rational design and IP strategies due to information on differential influence of mutated positions from paratope delineation
Used
Technologies

AbAccel™
Antibody
Optimization

Technologies
Related
Posters
Affinity Improvement of a Cross Reactive and Highly Stable Therapeutic Antibody
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Repeated 100-fold Affinity Improvements with AbAccel
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Our Services

Antibody
Discovery

Services

Antibody
Optimization

Services

Our Unique Platforms

Proprietary
Libraries

Technologies

Rabbit Mass
Humanization

Technologies

AbSieve™
Antibody
Selection

Technologies

AbAccel™
Antibody
Optimization

Technologies